The United States boasts some of the world’s largest and most advanced hospitals, each serving as a cornerstone of healthcare delivery, medical education, and research. These institutions not only provide comprehensive patient care but also contribute significantly to medical innovations and community health initiatives. As of 2025, here is an in-depth look at the top 10 largest hospitals in the U.S., ranked by bed capacity.
1. AdventHealth Orlando, Florida
AdventHealth Orlando stands as the largest hospital in the United States, with a capacity of 2,247 staffed beds. Located in Orlando, Florida, this institution is a flagship of the AdventHealth network, renowned for its comprehensive services across various specialties, including cardiology, oncology, neurology, and transplant services. The hospital’s expansive campus and state-of-the-art facilities cater to a diverse patient population, both regionally and nationally. AdventHealth Orlando’s commitment to innovation is evident through its integration of advanced medical technologies and a patient-centered approach, ensuring high-quality care and improved patient outcomes.
2. Jackson Memorial Hospital, Miami, Florida
With 1,547 beds, Jackson Memorial Hospital in Miami is one of the largest public hospitals in the nation. As the primary teaching hospital for the University of Miami Leonard M. Miller School of Medicine, it offers a wide range of services, including trauma care, organ transplants, and specialized pediatric care through its Holtz Children’s Hospital. Jackson Memorial is a vital safety-net hospital, providing care to a diverse and often underserved population, and is recognized for its cutting-edge research and comprehensive medical services.
3. Yale New Haven Hospital, Connecticut
Yale New Haven Hospital, with 1,541 beds, is a prominent academic medical center affiliated with Yale University. Located in New Haven, Connecticut, it offers a comprehensive range of services, including a renowned cancer center, children’s hospital, and psychiatric hospital. The institution is recognized for its commitment to research, education, and patient care, serving as a tertiary referral center for patients from across the region.
4. Cleveland Clinic Main Campus, Ohio
The Cleveland Clinic’s main campus in Cleveland, Ohio, comprises 1,285 beds and is internationally acclaimed for its cardiovascular care, urology, and gastroenterology programs. As a nonprofit, multispecialty academic medical center, it integrates clinical and hospital care with research and education. The Cleveland Clinic’s model of care emphasizes collaboration among specialists to provide comprehensive treatment plans tailored to individual patient needs.
5. Mayo Clinic Hospital – Saint Marys Campus, Rochester, Minnesota
Mayo Clinic’s Saint Marys Campus in Rochester, Minnesota, has 1,265 beds and is part of the larger Mayo Clinic Health System, renowned for its integrated clinical practice, education, and research. The hospital offers a wide array of specialties, including neurology, oncology, and transplant services, and is consistently ranked among the top hospitals globally for its commitment to patient care and medical innovation.
6. Barnes-Jewish Hospital, St. Louis, Missouri
Barnes-Jewish Hospital in St. Louis, Missouri, with 1,266 beds, is the largest hospital in Missouri and a key teaching hospital for the Washington University School of Medicine. It offers comprehensive services across all medical specialties and is recognized for its trauma and emergency medicine, as well as its transplant programs. The hospital’s commitment to research and education contributes significantly to advancements in medical science and patient care.
7. Atrium Health Carolinas Medical Center, Charlotte, North Carolina
Atrium Health’s Carolinas Medical Center, located in Charlotte, North Carolina, has 1,211 beds and serves as a regional referral center for comprehensive services, including trauma care, organ transplants, and specialty pediatric care. As the flagship hospital of Atrium Health, it plays a pivotal role in medical education and research, partnering with various academic institutions to train future healthcare professionals.
8. UAB Hospital, Birmingham, Alabama
The University of Alabama at Birmingham (UAB) Hospital, with 1,157 beds, is a leading academic medical center in the Southeast. It offers a full range of primary and specialty care services and is known for its comprehensive cancer center, cardiovascular services, and organ transplant programs. UAB Hospital’s integration with UAB’s research and educational missions fosters a collaborative environment that enhances patient care and medical discoveries.
9. Mount Sinai Hospital, New York City, New York
Mount Sinai Hospital in New York City has 1,134 beds and is part of the Mount Sinai Health System. It offers a wide range of medical and surgical services and is recognized for its excellence in geriatrics, cardiology, and gastroenterology. As a teaching hospital, it is affiliated with the Icahn School of Medicine at Mount Sinai, contributing significantly to medical research and education.
10. Indiana University Health Methodist Hospital, Indianapolis, Indiana
Indiana University Health Methodist Hospital, located in Indianapolis, has 1,125 beds and serves as a major referral center for Indiana and the Midwest. It offers comprehensive services, including a Level I trauma center, transplant programs, and specialized cardiovascular care. The hospital’s affiliation with the Indiana University School of Medicine enhances its commitment to research, education, and high-quality patient care.
These ten hospitals exemplify the scale and complexity of healthcare delivery in the United States. Each institution not only provides extensive bed capacity but also integrates cutting-edge medical technologies, research initiatives, and educational programs to advance the field of medicine. Their commitment to patient-centered care ensures that they continue to meet the evolving healthcare needs of their communities and the nation at large.